These three death modalities exhibit marked cell-type heterogeneity across neurons, microglia, astrocytes, and endothelial cells within the neurovascular unit, and converge on shared hubs of oxidative stress, mitochondrial dysfunction, and inflammatory signaling, forming a complex inter-pathway crosstalk network.
Dong-Yang Xing, Ke Xiang· Frontiers in Cell and Develo...· 0 citations
Results indicated that synergistic interactions among multiple CF1 components influence host metabolic pathways, in particular those involved in glycerophospholipid and amino acid metabolism, thereby suggesting an explanation for the alleviation of systemic metabolic dysregulation by the formulation.
Di Wu, Yanling Lin, Wenjun Guo et al.· Experimental Brain Research· 0 citations
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