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Author

Ke-Xin Xiao

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2 papers indexed here

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Open access Aug 2026

Structure-aware deep learning predicts influenza antigenicity and guides vaccine strain recommendation

The continuous accumulation of genetic mutations in influenza A viruses (IAVs) drives antigenic drift, necessitating precise antigenic prediction for optimal vaccine strain selection. While sequence-based methods have advanced antigenic surveillance, they neglect the three-dimensional structural context that fundamenta...

Xing-Yi Li, Chun-Yan Zhou, Ke-Xin Xiao et al. · 0 citations
Open access Sep 2026

VirPLM: Antigenic prediction of influenza A/H3N2 viruses with a fine-tuned protein language model.

MOTIVATION Human influenza A/H3N2 viruses undergo rapid antigenic evolution primarily driven by the hemagglutinin subunit 1 (HA1). Within HA1, amino acid substitutions under immune pressure cause antigenic drift, necessitating frequent updates to vaccine strains. While hemagglutination inhibition (HI) assays remain the...

Xing-Yi Li, Ke-Xin Xiao, Chun-Yan Zhou et al. · 0 citations

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