Ke-Yao Xia

Loss of transcriptional factor Zbtb33 fails to induce clonal hematopoiesis in mice but plays a role in tumor growth.

Clonal hematopoiesis (CH) is an early indicator of hematologic malignancies, driven by mutations in hematopoietic stem cells (HSCs) such as TET2 or P53. Recently ZBTB33 mutations have been implicated in myelodysplastic syndromes (MDS) and suggested as a driver of CH. However, the role of ZBTB33 in hematopoiesis and its...