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Author

Ke-Yu Zhang

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2 papers indexed here

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Oct 2026

Intaermedin attenuates chronic intermittent hypoxia-induced renal fibrosis via SIRT1-mediated inhibition of the NOX4/ROS axis.

Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by chronic intermittent hypoxia (CIH) and is an independent risk factor for chronic kidney disease (CKD); the underlying mechanism may involve oxidative stress. This study investigated the role of intermedin (IMD), a small antioxidant peptide, in CIH-in...

Yuan Ge, Yi-Lin Ren, Jun-Nan Guo et al. · 0 citations
Open access Sep 2026

Intermedin mitigates chronic intermittent hypoxia-induced metabolic reprogramming in tubular epithelial cells and attenuates consequent kidney fibrosis through an AMPK-dependent suppression of HIF-1α.

It is demonstrated that IMD alleviates CIH-induced metabolic reprogramming in TECs and curbs kidney fibrosis via AMPK activation and consequent HIF-1α signaling, indicating that IMD suppresses HIF-1α through an AMPK-dependent mechanism.

Yuan Ge, Juan Pan, Ya-Nan Li et al. · 0 citations

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