Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = ...
Madeline Wood Alexander, Jennifer S. Rabin, Michelle R. Caunca et al.· Nature Medicine· 1 citation
ABSTRACT Ageing biomarkers quantify molecular, physiological or functional features that vary between individuals as they age and may improve prediction of health outcomes beyond chronological age. Recently, plasma proteomics have been used to estimate the biological ages of 11 human organs. Although accelerated organ...
M. Pyrgioti, I. Eguiagaray, P. Redmond et al.· Aging Cell· 0 citations
Adverse childhood experiences (ACEs), including abuse, neglect, and household dysfunction, are among the most consequential adverse social experiences of early life and carry elevated risk of chronic disease and cognitive impairment in adulthood through biological pathways that are poorly understood. We examined the me...
Deborah K. Rose, Gabrielle N. Pfund, Robin Ortiz et al.· Brain, Behavior, & Immunity...· 0 citations
BACKGROUND
Demonstrating the specificity of plasma biomarkers to AD-related neurodegeneration would add support to their prognostic and diagnostic clinical use.
METHOD
Participants from the Baltimore Longitudinal Study of Aging were cognitively unimpaired at the time of their plasma Aβ42/Aβ40, GFAP, NfL (Quanterix Ne...
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· Alzheimer's & Dementia· 0 citations
Among CU individuals, plasma p-tau217 was associated with subsequent MCI/dementia due to AD and showed the most extensive associations with longitudinal AD-related brain atrophy, compared with SPARE-BA or R-indices capturing subcortical, diffuse cortical, or perisylvian atrophy.
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· medRxiv· 0 citations
Examination of associations of inherited chromosomally integrated human herpesvirus 6 with incident dementia and mortality, characterize proteomic and metabolomic correlates of carrier status, and evaluate whether these biomarkers relate to dementia and mortality risk found iciHHV‐6 was associated with increased dement...
M. Beydoun, Minkyo Song, Choa Yun et al.· Alzheimer's & Dementia· 1 citation
PVWMH demonstrate larger effects on declining cognitive function than DWMH, particularly for motor and processing speed functions and progress at a faster rate, particularly for motor and processing speed functions and progress at a faster rate.
Sarvin Sasannia, M. Matsyuk, Shimeng Wang et al.· Stroke· 0 citations
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