Glucocorticoid Receptor-Mediated Engineered Cancer Stem Cell-Led Therapy and Inhibition of Recurrence in Colorectal Cancer
Dysregulated wnt/β-catenin signaling cascades drive self-renewal, proliferation, differentiation, and therapeutic resistance in cancer stem cells (CSCs), thus contributing to their tumor aggression and poor clinical outcomes. Earlier, we demonstrated that a glucocorticoid receptor (GR)-targeted liposomal formulation...