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Author

Keiko Muguruma

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Open access Jul 2026

Neurogenesis defects in iPSC-derived midbrain organoids of early-onset Parkinson's disease with 22q11.2 deletion syndrome

These findings suggest that, in early-onset PD patients with 22q11.2 DS or PRKN mutation, enhanced neurogenesis could result in reduced number of dopaminergic neurons during early development, which indicates that the onset of PD may occur as early as the embryonic stage.

Syugo Ueki, Toshiya Kimura, Rie Tohge et al. · 0 citations