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Author

Keimpe D. Wierda

2 papers indexed here

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Open access Aug 2026

ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis

Polyamines, such as spermidine, are essential regulators of brain development, yet how cells control their uptake and extracellular levels remains unclear. Here we show that ATP13A4, a transport protein enriched in glia and prominently expressed in astrocytes, governs brain polyamine balance. Using biochemical, cellula...

S. van Veen, Emily Meeus, D. Irala et al. · 1 citation
Open access Aug 2026

Developing mouse inhibitory neuron single-cell transcriptomes reveal distinct modes of cell-type diversification

The cerebral cortex depends on a diverse repertoire of inhibitory neurons, yet how this diversity emerges during development remains unclear. Rare inhibitory subtypes are often underrepresented in single-cell RNA-sequencing datasets, limiting resolution of their developmental trajectories. Here we developed a computati...

Minhui Liu, Facundo Ferrero Restelli, Elia Micoli et al. · 0 citations

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