Open access
Jul 2026
Epigenetic Reactivation of Lineage Differentiation to Target Leukemia
A selective small-molecule TRIM28 inhibitor is developed that binds the TRIM28 PHD-bromodomain, phenocopies TRIM28 loss across biochemical and cellular assays, exhibits low micromolar anti-leukemia activity, induces neutrophil differentiation, and synergizes with Menin inhibition.
Shandon M. Amos, Chi-Chao Chen, Yichen Xiang et al.
· bioRxiv · 0 citations