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Kellen Doggett

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Open access Oct 2026

Limitations of differential expression for cell-type marker discovery in single-cell RNA sequencing atlases

Cell-type marker genes are definitional characteristics of a cell type, and in single-cell RNA sequencing atlases they are commonly nominated through differential expression (DE) testing. The Wilcoxon rank-sum test is the default method for marker gene discovery in Seurat and a recommended method in Scanpy, two widely...

Kellen Doggett, D. Pintard, Richard H. Scheuermann et al. · 0 citations

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