Jul 2026
A novel microbial-derived metabolite counteracts exhaustion programming in CD8 T cells 2260531
These findings identify a novel microbial SCFA as a potential metabolic-epigenetic regulator, capable of reactivating effector programs in TEX cells while blocking terminal exhaustion, and provide insights into developing new therapeutic approaches to reprogram TEX cells and enhance the efficacy of T cell immunotherapy.
Asmaa M. Yousif, Amira Yousif, Ava Lowin et al.
· Journal of Immunology · 0 citations