Conventional and hydrolysable PEGs: comparative evaluation of tissue accumulation, biodistribution and toxicological profile.
PEG has been commonly considered safe and is widely used in pharmaceutical and personal care products. Concerns about its safety arised in relation to studies demonstrating its accumulation in some organs of animals treated with very high PEG dosages (e.g., 200 mg per kg per week for up to 12 weeks). Although these dos...