Author

Ken-ichi Yamada

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Open access Sep 2026

Oxidized phosphatidylinositol impairs lysosomal membrane repair to promote ferroptosis

Results indicate that the oxidized phospholipids identified here may serve as markers of ferroptosis while also acting as bioactive mediators that compromise lysosomal membrane homeostasis and repair.

Shota Fukuyama, Ping-Yen Hsieh, Yuka Jinnouchi et al. · bioRxiv · 0 citations

Open access Jul 2026

TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism

These findings identify TMEM135 as a central regulator of hepatic lipid metabolism and uncover a coordinated mechanism linking lipid availability, lipogenesis, and post-translational metabolic regulation.

Ryo Hagimori, Michael Landowski, Siyu Song et al. · bioRxiv · 0 citations