Ken Murakami

Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo

Enhancers control tissue-specific gene expression across animals1. Although deep learning2,3 has enabled enhancer prediction and design in mammalian cell lines and non-mammalian model organisms4, 5, 6, 7, 8, 9–10 (reviewed in a previous publication11), it remains unclear whether such approaches can operate within the r...