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Open access Sep 2026

The Landscape of Tumor Dissemination in Leptomeningeal Disease: Mapping CTC Plasticity and Regional Heterogeneity Across Blood and CSF Compartments

Background/Objectives: Leptomeningeal disease (LMD) is among the most severe complications of metastatic breast cancer, with median survival measured in weeks. Definitive diagnosis relies on neuroimaging and cerebrospinal fluid (CSF) cytology, which carries a false-negative rate of 40–50% at a single lumbar puncture. I...

Stephanie N. Shishido, Baishali Chaudhuri, Vidur Mushran et al. · 0 citations
Open access Aug 2026

T cells are critical for pre-metastatic niche formation through the STAT3/IL-17 axis

It is demonstrated that CD4+ T cells accumulate in tumor-free lungs and promote tumor metastasis in mouse models, and STAT3 and IL-17 in CD4+ T cells therefore are important for pre-metastatic niche formation and metastasis.

Maciej Kujawski, Antons Martincuks, M. Song et al. · 0 citations

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