Author

Keng-Chang Tsai

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Open access Sep 2026

Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer

This study identifies TXNRD1 as a crucial regulator of cellular plasticity and metastasis in NSCLC via the TGF-β1 pathway, suggesting that targeting TXNRD1 may reduce metastatic potential and improve patient survival.

Yaw-Dong Lang, Shin-Yuan Gu, Jou-Ho Shih et al. · Cancer Biology & Therapy · 0 citations

Open access Aug 2026

Isorhoifolin regulates S1PR3-CK2-GSK3β axis and promotes neurite regrowth and functional recovery after traumatic brain injury.

A neuron-centric role for S1PR3 in regulating structural repair is delineated that is mechanistically distinct from the known functions of S1PRs in immune cells and defines mechanistically distinct yet coordinated neuronal and astrocytic pathways that are responsible for isorhoifolin-enhanced structural and functional...

Yi Wang, Wen-Lin Liao, Chen Wang et al. · Phytomedicine · 0 citations