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Author

Kenji Ohgane

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Open access Sep 2026

Discovery of PROTACs recruiting the E3 ligase CHIP

Proteolysis-targeting chimeras (PROTACs) are promising degraders in targeted protein degradation (TPD) systems. Although more than 600 E3 ubiquitin (Ub) ligases exist in the human genome, only a few E3 ligases have been engaged in PROTACs. It is essential to expand the range of available E3 ligase resources to combat d...

Tokiha Masuda-Ozawa, Shusuke Tomoshige, E. Hayakawa et al. · 0 citations

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