Kenneth Lap-Kei Wu

System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation

Significance Serotonin shapes nearly every brain circuit and is a major target of psychiatric drugs, yet how its widespread pathways are assembled has remained unclear. We combined whole-brain developmental mapping with single-cell RNA profiling to show that forebrain-projecting serotonin neurons are specified into sub...