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Author

Kenya Tanaka

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Open access Sep 2026

Coupling fatty acid biosynthesis to β-oxidation enhances the biosynthesis of malonyl-CoA-dependent polyketides.

Malonyl-CoA is a major extender unit in polyketide biosynthesis; however, in Escherichia coli, it is predominantly consumed by fatty acid biosynthesis, limiting its availability for heterologous polyketide production. Here, we engineered a fatty acid biosynthesis-β-oxidation carbon-recycling pathway (FABOX pathway) tha...

Takatoshi Suematsu, Shumpei Asamizu, Manami Takama et al. · 0 citations
Jul 2026

Heterologous polyhydroxyalkanoate synthase expression enables poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) production from fatty acids in Rhodobacter capsulatus.

This study demonstrates PHBH biosynthesis in R. capsulatus and indicates that limited 3HHx-CoA supply rather than polymerization capacity is the primary bottleneck, providing a foundation for further pathway and host optimization toward flexible PHBH production from diverse substrates.

Kako Miura, Takayuki Shimizu, T. Hasunuma et al. · 0 citations

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