Open access
Aug 2026
A cryptic allosteric pocket shapes isoform‐selective inhibition of human malic enzymes
Malic enzymes (ME) regulate central carbon metabolism and cellular redox balance, and the mitochondrial isoform ME2 is frequently upregulated in aggressive cancers to support metabolic flexibility and stress resistance. Isoform‐selective inhibition has remained out of reach because the catalytic machinery is essentiall...
Ben A. Krinkel, Y. Yosaatmadja, M. Slayton et al.
· Protein Science · 0 citations