Open access
Jul 2026
DirectContacts2: a wiring diagram of human physical protein interactions
The authors develop a machine learning classifier through the integration of 25,000 proteomics experiments to construct a wiring diagram of human cells, which enables structural modeling of disease-relevant complexes and establishes a highly accurate protein wiring diagram of the cell.
Erin R. Claussen, Miles D. Woodcock-Girard, Samantha N. Fischer et al.
· Nature Communications · 0 citations