Open access
Aug 2026
Protein design to broadly reprogram engineered T cell function
OutLAST Regulators are designed proteins that reprogram critical T cell signaling pathways to enhance functional persistence and are implemented as compact genetic modules compatible with standard viral vectors and cell therapy manufacturing processes, creating a powerful platform for programming new functions into enhanced cell and gene therapies.
S. Boyken, Sean A Merillat, Robert A. Langan et al.
· bioRxiv · 0 citations