Author

Kevin J. Curran

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Sep 2026

Abstract A003: Safety and efficacy of autologous tumor infiltrating lymphocyte therapy in pediatric and adolescent patients with immune checkpoint inhibitor-refractory metastatic melanoma: Results from a phase I clinical trial

Lifileucel is an autologous tumor infiltrating lymphocyte (TIL) therapy approved for adults with unresectable or metastatic melanoma previously treated with a PD-1 inhibitor and/or targeted therapy. Pediatric data have been lacking. We report preliminary safety, feasibility, and efficacy results from the melanoma...

S. Sait, J. Honeyman, S. Stapleton et al. · Cancer Research · 0 citations

Open access Jul 2026

IL7-Receptor–Targeted CAR T-Cell Therapy for T-Cell Acute Lymphoblastic Leukemia

The authors propose IL7-Receptor (IL7R/CD127) as an alternative target for T-ALL and propose IL7-Receptor/CD127 CAR-T cells as an alternative target for T-ALL, showing the antitumor efficacy of IL7Rα/CD127 CAR-T cells against T-ALL in preclinical models.

H. Hocine, Undrakh Ganbaatar, Alfredo Amador-Molina et al. · Nature Communications · 0 citations