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Author

Kevin Messacar

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Clinical trial Open access Sep 2026

Cephalexin Model-Informed Dosing Recommendations for Severe Infections: A Pooled Pharmacokinetic Analysis From Infancy to Adulthood

Abstract Background Cephalexin is increasingly used as initial and oral transition therapy for severe infections, but optimal dosing in this setting remains uncertain. Methods Four cephalexin pharmacokinetic (PK) datasets spanning preterm neonates through young adults were pooled to develop a unified population PK mode...

Andrew S. Haynes, D. Gonzalez, Kevin Messacar et al. · 0 citations
Review Open access Sep 2026

Clinical Characteristics of Enterovirus D68 (EV-D68) Respiratory Disease in Colorado Children Over a Decade: 2014–2025

Children with EV-D68 respiratory disease commonly presented with severe asthma-like respiratory disease, even in those without atopy, and children quickly improved over short hospitalizations when managed with bronchodilators, steroids, and respiratory support.

Hai Nguyen-Tran, Molly Butler, Dennis Simmons et al. · 0 citations
Open access Aug 2026

Vaccine imprinting drives increased SARS-CoV-2 variant infection in children

The dependence of effective variant-specific antibodies on vaccination history is shown which may explain birth-year influence on differential susceptibility to SARS-CoV-2 variants XFG and BA.3.3.2, and it is suggested that vaccination regimens in children should prioritize neutralization breadth.

T. Johnston, Rahul Subramanian, Wakinyan Benhamou et al. · 0 citations

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