Abstract B103: Interleukin-1 Receptor Accessory Protein (IL1RAP) is a Critical Determinant of Neutrophil Trafficking in Pancreatic Cancer
A dominant mechanism of chemoimmunotherapy resistance in PDAC is the robust infiltration and persistence of neutrophilic or polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). Interleukin-1 receptor accessory protein (IL1RAP) is the co-receptor for the IL-1 superfamily cytokines which drive inflammato...