Review
Open access
Jan 2026
Beyond mitotane: next-generation therapeutic landscapes in adrenocortical carcinoma
The clinical management of adrenocortical carcinoma (ACC) has long been defined by its resistance to conventional therapies. Since the FIRM-ACT trial established the combination of etoposide, doxorubicin, and cisplatin plus mitotane (EDP-M) as the frontline standard, overall survival for metastatic patients has remaine...
Keya Kotecha, Katia Mariniello, L. Guasti
· Endocrine Oncology · 0 citations