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Author

Keyu Chen

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Open access Oct 2026

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

ABSTRACT The early‐stage hippocampal development depends on precise synaptic remodeling, processes where microglia play indispensable roles. Disruption of this event reshape hippocampal neural circuit architecture and heighten the risk for long‐term memory, learning, and behavioral deficits. Manganese (Mn), a widesprea...

Ke-Yu Chen, Bin He, Kuan Liu et al. · 0 citations
Sep 2026

Melatonin ameliorates manganese-induced neurological deficits in mice by inhibiting TXNIP signaling-mediated neuroinflammation and microglial pyroptosis: Role of SIRT6.

Manganese (Mn) overexposure induces neurocognitive deficits associated with hippocampal neuronal injury and neuroinflammation, but the cellular mechanisms underlying Mn-induced hippocampal damage remain incompletely understood. Microglial pyroptosis may amplify neuroinflammation and contribute to secondary neuronal inj...

Jia Liu, Ji-Xing Liang, Keyu Chen et al. · 0 citations

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