Melatonin Supplementation in the Management of Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis.
BACKGROUND Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction characterized by recurrent abdominal pain and altered bowel habits, with substantial effects on quality of life and healthcare utilization. Melatonin has been proposed as a potential adjunctive therapy because of its effects on visc...