Author

Khaled S. Abd-Elrahman

2 papers indexed here

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Open access Aug 2026

TRIM9 Determines Sex-Specific β-Amyloid/Cellular Prion Protein/mGluR5 Complex Formation and Pathological Signaling in Alzheimer’s Disease Mice

Biological sex is a major determinant of Alzheimer’s disease prevalence, yet the molecular mechanisms underlying sex-specific vulnerability remain largely unknown. Metabotropic glutamate receptor 5 (mGluR5) functions as a co-receptor for β-amyloid (Aβ42) oligomer/cellular prion protein (PrPC)-mediated pathogenic signal...

Fatemeh Babaei, Fatemeh A. Panahi, Tash-Lynn L. Colson et al. · bioRxiv · 0 citations

Open access Aug 2026

Restoring neurovascular coupling in Alzheimer’s disease tauopathy through M1 mAChR modulation

It is demonstrated that M1 mAChR positive allosteric modulation reverses tau-induced neurovascular dysfunction, supporting M1 mAChR activation as a promising disease-modifying approach for Alzheimer’s disease and suggesting that therapeutic efficacy is influenced by biological sex.

Wesam Bassiouni, Mohamed Abdelnaby, En-Hung Ai et al. · bioRxiv · 0 citations