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Kieran Monahan

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Open access Sep 2026

A water-pinning hotspot drives templated tau aggregation

This study shows recruitment begins at a single, structurally well-defined contact site on the fibril surface that is enriched in release-prone hydration water, revealing that water-release-prone hotspots govern the initial steps in templating seeding and can hence be blocked, opening a new path for identifying therape...

Chung-Ta Han, Karen Tsay, Samuel Lobo et al. · 0 citations

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