Kilian Maidhof

Robust ORF Deconvolution from Multiple Ribo-seq Datasets with Group LASSO Penalty

Ribo-seq has provided compelling evidence that there are many translated but unannotated ORFs. Despite a growing body of peptidomic support for cryptic ORFs, the computational discovery of weakly translated, short and mutually overlapping ORFs has remained a major bottleneck. Here we introduce PRICE 2, a method designe...