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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Kimberly A. Foster

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2 papers indexed here

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Aug 2026

Discovery of BMS-986449: A Potent, Selective Degrader of the Transcription Factors IKZF2 (Helios) and IKZF4 (Eos) to Target Regulatory T Cells in Solid Tumors.

BMS-986449 is an orally available degrader that demonstrates single-agent growth inhibition of syngeneic MC38 tumors implanted in humanized Cereblon (CRBN) knock-in mice and establishes BMS-986449 as a promising clinical candidate for cancer immunotherapy.

E. Cherney, S. Nair, Suresh Babu Viswa Krishna Penmetsa et al. · 1 citation
Sep 2026

Mechanistic Insights into Drug Release from PLGA- and PLA-Based Implants

The results establish how polymer chemistry, polymer mobility, and drug physicochemical properties collectively determine release performance, providing a mechanistic basis for designing biodegradable implants with tunable profiles.

Dong-Yue Yu, Ryan V. Schroder, Arnold Teo et al. · 0 citations

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