Kimberly A. Kelly

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Background Pancreatic adenocarcinoma (PDAC) is an abysmal disease with poor clinical outcomes, largely due to limited life-extending treatments. Notably, PDAC displays a T cell-suppressive tumor microenvironment, and the underlying molecular mechanisms that lead to this phenotype remain poorly understood. Methods Utili...