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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Kimberly Gomez

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3 papers indexed here

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Open access Sep 2026

A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability

Pain is a prevalent and disabling symptom of myotonic dystrophy type 1 (DM1), yet its underlying mechanisms remain poorly understood. Using HSA LR20b transgenic mice, we found multimodal mechanical and thermal hypersensitivity. Whole-cell electrophysiological recordings demonstrated depolarized resting membrane potenti...

Tyler S. Nelson, Aida Calderon-Rivera, Sara Hestehave et al. · 0 citations
Open access Sep 2026

Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics.

These findings establish a link between myotonia and persistent alterations in nociceptive processing and identify NaV1.8-directed analgesia as a promising therapeutic strategy for myotonia-associated pain.

Tyler S. Nelson, Aida Calderon-Rivera, Heather N. Allen et al. · 1 citation · ⚡1
Open access Sep 2026

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson’s disease

It is demonstrated that dopaminergic neurodegeneration initiated within the brain is sufficient to drive persistent peripheral sensory neuron dysfunction and identify CRMP2-dependent regulation of NaV1.7 as a therapeutic target for Parkinsonian pain.

Tyler S. Nelson, Naomi K. Grabus, Heather N. Allen et al. · 1 citation

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