Discovery and Optimization of Imidazothiazole Carboxamides as Novel Anti-Tuberculosis Agents
Screening of the open-access CRESTdb small-molecule library identified the imidazothiazole carboxamide sCQG200 (1) as an initial hit, with activity against H37Rv and Erdman Mycobacterium tuberculosis strains in cholesterol-containing medium (MIC90= 6.88 µM and 4.48 µM, respectively) and against intracellular Mtb (EC50=...