Author

Konstantin Bräutigam

2 papers indexed here

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Open access Oct 2026

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

It is shown that the neoplastic evolution of mismatch repair deficient (MMRd) clones leads to large-scale and sustained reorganisation of the T-cell repertoire in colon and peripheral blood, which defines the local and circulating TCR landscape associated with colonic neoplasia in Lynch syndrome and provides a framewor...

Penelope V. Edwards, O. Swinyard, T. Ronel et al. · bioRxiv · 0 citations

Open access Jul 2026

Gene mutant dosage is associated with prognosis and metastatic tropism in 60,000 clinical cancer samples

An open-source Bayesian inference tool that determines the multiplicity and copy number of driver mutations from tumor sequencing datasets is presented, an open-source Bayesian inference tool that determines the multiplicity and copy number of driver mutations from tumor sequencing datasets.

N. Calonaci, E. Krasniqi, D. Čolić et al. · Nature Genetics · 0 citations