Open access
Oct 2026
Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen
SUMMARY Acanthamoeba castellanii causes infectious blindness and is a key evolutionary outgroup to humans and fungi. Its divergent mitochondria are of outstanding interest due to predicted aerobic and anaerobic functions with potential for drug targeting. However, a detailed delineation of its bioenergetic machinery, t...
Jonathan A. Stefely, Felicia Deng, Michael Z. Chen et al.
· Cell · 6 citations