Author

Kranti Kiran Reddy Ealla

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Review Open access Sep 2026

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer stem cells (CSCs) are increasingly recognized as metabolically plastic subpopulations within malignant tissues that drive tumor initiation, metastatic dissemination, and relapse after therapy. Although traditional models of cancer metabolism have emphasized aerobic glycolysis, CSCs rarely exhibit a single, clear...

D. E. Uti, E. U. Alum, J. Egbung et al. · Cancer Medicine · 0 citations

Review Open access Jul 2026

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

This review traces the evolution of PROTAC technology, delineates the challenges of conventional delivery, and evaluates the rationale for exosomal encapsulation, including cargo protection, intracellular trafficking, endosomal escape, and release kinetics and outlines future directions for exosome‐mediated targeted pr...

S. Ghosh, R. Banerjee, Hailah M. Almohaimeed et al. · Journal of Cellular and Mole... · 0 citations