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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Kristen M. Naegle

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Sep 2026

Abstract PR012: Encoding adaptive mechanisms of resistance to KRAS inhibition in pancreatic cancer

This study defines adaptive resistance mechanisms to KRAS-targeted therapy in PDAC, revealing both cell-state-dependent RTK rewiring and a conserved SFK adaptive signaling axis and provides a mechanistic rationale for either KRAS/pan-RAS or pan-RAS/SFK co-inhibition as strategies to improve responses to KRAS-targeted t...

Qing-Xiang Lin, Bo-Kai Song, C. Sander et al. · 1 citation
Open access Aug 2026

Studying the effect of conserved tyrosine phosphorylation within SH2 domains

Specific tyrosine residues within the PTPN11-N, LYN, and SYK-C SH2 domains are studied, finding that the PTPN11 N-terminal site (Y63) modulates the specificity, reducing binding of physiologically relevant substrates.

Gabrielle Martinez, Mindolay Fike, Madhuri Sosale et al. · 0 citations
Open access Aug 2026

SpY-C: Supervised Learning of Phosphopeptide Sequence Constraints Enables Global Prediction of SH2 Domain Binding

SpY-C is used as a classifier to annotate the human phosphoproteome and individual experiments, to explore the consequences of using super-SH2 domain reagents for pY enrichment, and to analyze the effects of mutations in altering pY site function.

Alekhya Kandoor, Anny Carolline Silva Oliveira, K. Machida et al. · 1 citation

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