Open access
Aug 2026
An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy
BRAF mutant colorectal cancer (CRC) remains difficult to treat despite the clinical use of combined BRAF and EGFR inhibition, highlighting a need to define tumour-intrinsic mechanisms that limit therapeutic response. Here, using genome-wide CRISPR-Cas9 screening in BRAF-mutant CRC cells, we identify MEN1, encoding the...
Akash Srivaths, Aleen Al Halawani, Tirta M. Djajawi et al.
· bioRxiv · 0 citations