Author

Kristian Schweimer

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Open access Aug 2026

Transient interdomain interactions shape the conformational ensemble governing RNA recognition by the tandem RRMs of Sex-lethal

It is demonstrated that RNA recognition by Sxl is governed not by a single apo structure but by a finely balanced conformational ensemble, and that perturbing this equilibrium in either direction compromises high-affinity and sequence-selective RNA binding.

Julia Meyer, Kristian Schweimer, P. Matzner et al. · bioRxiv · 0 citations