Author

Kristian Vissing

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Open access Sep 2026

Fibro-adipogenic Progenitor and Macrophage Remodeling of the Aging Skeletal Muscle Niche During Exercise-Induced Hypertrophy

Fibro-adipogenic progenitors (FAPs) have emerged as central regulators of the skeletal muscle homeostasis and the muscle microenvironment. However, the role of FAPs in the context of exercise-induced muscle hypertrophy remains largely unexplored. Here, we utilized six weeks of blood flow restricted resistance exercise...

Jakob Wang, Jonas Brorson, Søren Kuhdal et al. · bioRxiv · 0 citations

Open access Aug 2026

Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle.

The findings reveal that mechanosensitive anabolic signaling is differentially affected by aging, and suggests that age-related deficits observed in vivo may, at least in part, arise from systemic influences rather than intrinsic defects adhering to mTORC1 mechanotransduction.

J. B. Kristiansen, Jacob Andresen, Jesper Emil Jakobsgaard et al. · Experimental Gerontology · 0 citations