Open access
Sep 2026
Extraintestinal Reprogramming of Colon-Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut-Joint Axis.
OBJECTIVE The gut-joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is TCRαβ+ CD4+ intraepithelial lymphocytes in the colon (cIELs) that can traffic to extraintestinal tissues, including the joint. Within...
S. M. Danielson, Connor Eck, Su-Cai Liu et al.
· Arthritis & Rheumatology · 0 citations