MtbAIM: AI/ML-guided endpoint-specific prediction of small-molecule activity across drug-susceptible and drug-resistant Mycobacterium tuberculosis
The emergence of drug resistance in Mycobacterium tuberculosis (M.tb) presents a major challenge to drug discovery, as compounds active against drug-susceptible (DS) isolates may not retain comparable inhibitory activity against drug-resistant (DR) isolates. Here, we developed an AI/ML workflow to independently priorit...