Maternal–Fetal Exposome and Early-Life Microbiota–Pattern Recognition Receptors Signaling in Inflammatory Bowel Disease Susceptibility: A Mechanistic Review
A testable “developmental inflammatory set-point” model in which cell type, tissue compartment, timing, signal intensity, and host genotype determine whether microbial sensing promotes tolerance or persistent inflammatory readiness is proposed, which is biologically plausible but remains unvalidated as a predictor of h...