Neurodegenerative Diseases (NDs) represent a growing global health challenge, characterized by progressive neuronal loss and cognitive decline. Central to these disorders are tauopathies, characterized by abnormal aggregation and hyperphosphorylation of tau proteins, leading to synaptic dysfunction and neuronal degener...
Kuldeep Singh, Shiv Narayan, Pranshul Sethi et al.· Current molecular medicine· 0 citations
The synthesis of emerging evidence regarding the neuroprotective efficacy of phytotherapy is presented in this review, and the focus is on such traditional medicinal plants as Bacopa monnieri, Withania somnifera, and Centella asiatica.
Shatrudhan Prajapati, Shikha Yadav, A. Singh et al.· Current Pharmaceutical Biote...· 0 citations
Key therapeutic approaches discussed include gene-silencing technologies such as antisense oligonucleotides, RNA interference, and CRISPRCas9- based strategies, as well as small-molecule modulators targeting mutant huntingtin aggregation, proteostasis, autophagy, mitochondrial dysfunction, and neuroinflammation.
B. Semwal, Kuldeep Singh, Ritesh Sharma et al.· Current Pharmaceutical Biote...· 0 citations
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