Kumaran Narayanan

Overcoming Cellular Barriers with Cell-Penetrating Peptides: Functional Roles of Individual Amino Acids.

The delivery efficiency of cell-penetrating peptides (CPPs) is much lower than that of other non-viral delivery systems, mainly because of cellular barriers such as the plasma membrane, endosomal acidification, cytosolic degradation, and nuclear entry. The plasma membrane is a significant extracellular barrier that reg...