Gout is a metabolic disorder characterized by hyperuricemia, which results in the deposition of monosodium urate crystals in joints, leading to recurrent episodes of inflammation, pain, and progressive joint damage. Xanthine oxidase (XO), the key enzyme involved in the final steps of uric acid biosynthesis, is an impor...
Samiksha Kondhare, Kumudini Pawar, Sneha Pawar et al.· Journal of Drug Design and M...· 0 citations
It is suggested that Tripterygium wilfordii exerts anti-rheumatic activity through a multi-component, multi-target, and multi-pathway mode of action, providing valuable insights into its pharmacological basis and supporting its potential as a promising therapeutic candidate for rheumatoid arthritis.
Rohan Mohite, Pragati Pujari, Sneha Pawar et al.· Modern Chemistry· 0 citations
A reliable, innovative and stability-indicating HPTLC method was successfully developed and validated for estimating inosine pranobex (IP) in both bulk drug and pharmaceutical formulations using a Quality by Design (QbD) approach. To achieve systematic optimization, a Box-Behnken Design was applied to identify and refi...
Simran M. Jamadar, Priyanka G. Kale, Kumudini Pawar· Indian drugs· 0 citations
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