Portulaca oleracea L.-Derived extracellular vesicles alleviate renal lipotoxicity in diabetic kidney disease by regulating the NLRP3 pathway.
BACKGROUND Diabetic kidney disease (DKD) remains a leading indication for renal replacement therapy, with existing drugs having many limitations. Portulaca oleracea L.-derived extracellular vesicles (PO-EVs) exhibit anti-inflammatory, antioxidant, and immune-regulatory properties. However, their function in DKD has yet...