Biomimetic Self-Adhesive Artificial Periosteum with Micro/Nanofibrous Structure Accelerates Bone Reconstruction via Synergistic Osteogenesis and Angiogenesis.
Critical-sized bone defects remain a major clinical challenge, and the periosteum, comprising a highly vascularized outer fibrous layer and an osteogenic inner layer, is crucial for bone repair. Herein, a biomimetic bilayer artificial periosteum (CP-HP) was developed, consisting of a hierarchically aligned micro/nanofi...